Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells
نویسندگان
چکیده
منابع مشابه
Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells
HoxB4, a homeodomain-containing transcription factor, is involved in the expansion of hematopoietic stem cells and progenitor cells in vivo and in vitro, and plays a key role in regulating the balance between hematopoietic stem cell renewal and cell differentiation. However, the biological activity of HoxB4 in other cells has not been reported. In this study, we investigated the effect of overe...
متن کاملInterferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
The malignant, CD5+ B lymphocytes of B cell chronic lymphocytic leukemia (B-CLL) die by apoptosis in vitro. This is in contrast to the prolonged life span of the leukemic cells in vivo and likely reflects the lack of essential growth factors in the tissue culture medium. We found that interferon gamma (IFN-gamma) inhibits programmed cell death and promotes survival of B-CLL cells in culture. Th...
متن کاملUptake of pro-apoptotic peptide amphiphiles by SJSA-1 cells in vitro induces specific cell death
Dimitris Missirlis and Matthew Tirrell Department of Bioengineering, University of California at Berkeley Statement of Purpose: Self-assembled micelles composed of peptide amphiphiles (PAs) have recently been shown to actively target specific tissues following introduction to the systemic circulation. Experiments with mixed micelles, incorporating two different PAs, demonstrated that despite th...
متن کاملInterleukin-10 inhibits apoptotic cell death in infectious mononucleosis T cells.
T lymphocytes from patients with acute EBV-induced infectious mononucleosis rapidly die by apoptosis in vitro. Because human and viral IL-10 are likely to be induced during acute EBV infection and display a variety of functions on human T cells, we examined IL-10 effects on infectious mononucleosis T cell death. After 12 h of incubation in medium alone, only 35.6 (+/- 8.2%) of the originally se...
متن کاملGarlic Extract Can Induce Apoptotic Cell Death in The Human Colon Adenocarcinoma HT29 Cell Line
Background and Objective: Garlic has been known worldwide as a dietary constituent with many pharmacological effects. The present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. Material and Methods: Human colon adenocarcinoma cells HT29 were treated with different doses (1, 5 a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Korean Journal of Physiology & Pharmacology
سال: 2012
ISSN: 1226-4512,2093-3827
DOI: 10.4196/kjpp.2012.16.4.265